Accueil Accueil

Journées Inaugurales du Centre de Recherche en Neurosciences de Lyon (CRNL)
c7-The neural correlates of conscious awareness revealed by the study of coma & related states (3907) - Mardi 25 septembre 2012 17:00 - 17:30

c7-The neural correlates of conscious awareness revealed by the study of coma & related states

The past 15years have provided an unprecedented collection of discoveries that bear upon our scientific understanding of recovery of consciousness in the human brain following severe brain damage. Highlighted among these discoveries are unique demonstrations that patients with little or no behavioral evidence of conscious awareness may retain critical cognitive capacities and the first scientific demonstrations that some patients, with severely injured brains and very longstanding conditions of limited behavioral responsiveness, may nonetheless harbor latent capacities for recovery. Included among such capacities are particularly human functions of language and higher-level cognition that either spontaneously or through direct interventions may reemerge even at long time intervals or remain unrecognized.
When patients in “persistent vegetative state” (recently coined unresponsive wakefulness syndrome) show minimal signs of consciousness but are unable to reliably communicate the term minimally responsive or minimally conscious state (MCS) is used. MCS was recently subcategorized based on the complexity of patients' behaviors: MCS+ describes high-level behavioral responses (i.e., command following, intelligible verbalizations or non-functional communication) and MCS- describes low-level behavioral responses (i.e., visual pursuit, localization of noxious stimulation or contingent behavior such as appropriate smiling or crying to emotional stimuli). Patients who show non-behavioral evidence of consciousness or communication only measurable via ancillary testing (i.e., functional MRI, positron emission tomography, EEG or evoked potentials) can be considered to be in a functional locked-in syndrome.
Taken together, recent studies show that awareness is an emergent property of the collective behavior of frontoparietal top-down connectivity. Within this network, external (sensory) awareness depends on lateral prefrontal/parietal cortices while internal (self) awareness correlates with precuneal/mesiofrontal midline activity. Of clinical importance, this knowledge now permits to improve the care of patients with disorders of consciousness.
References:
Coma and consciousness: Paradigms (re)framed by neuroimaging. Laureys S and Schiff ND. Neuroimage. 2011 Dec 27. [Epub ahead of print]

Audrey Vanhaudenhuyse, Steven LAUREYS, Coma Science Group, University and University Hospital of Lie?ge, Belgium

Sciences du Vivant Communication

Toutes les vidéos de l'évenement Journées Inaugurales du Centre de Recherche en Neurosciences de Lyon (CRNL) (20 videos)

00:28:00.03

2012-09-25

10:45 - 11:45 : Ouverture du colloque

00:27:55.04

2012-09-25

11:45 - 12:15 : Brain against brain: presentation of a new brain computer interfa...

00:35:06.02

2012-09-25

14:30 - 15:00 : C2-Multiple level interactions between neurodegeneration and neur...

00:19:24.03

2012-09-25

15:00 - 15:20 : C3-Serotonin receptors and neurodegenerative processes. A Focus o...

00:18:55.03

2012-09-25

15:20 - 15:40 : c4-VEGF in neuronal development and synaptic plasticity

00:19:42.03

2012-09-25

15:40 - 16:00 : C5-Mutations in U4atac small nuclear RNA: from splicing to brain ...

00:36:52.02

2012-09-25

16:30 - 17:00 : c6-Homeostatic regulation of neural activity across the sleep- wa...

00:30:35.02

2012-09-25

17:00 - 17:30 : c7-The neural correlates of conscious awareness revealed by the s...

00:20:25.03

2012-09-25

17:30 - 17:50 : c8-Cognition markers in altered states of consciousness

00:26:26.03

2012-09-25

17:50 - 18:10 : C9-The multiple faces of wakefulness, histaminergic and orexinerg...

00:19:02.02

2012-09-25

18:10 - 18:30 : c10-Mechanisms responsible for Paradoxical (REM) sleep genesis: w...

00:38:35.02

2012-09-26

09:30 - 10:00 : c12-How temporal expectations change perception

00:24:37.04

2012-09-26

10:20 - 10:40 : c14-High-frequency neural activity and human cognition: insights ...

00:20:35.04

2012-09-26

10:40 - 11:00 : c15-Neuroimagery of olfactory perception and memory in humans

00:20:49.02

2012-09-26

11:00 - 11:20 : c16-Language, music, complex sounds: What to expect?-And when

00:32:32.04

2012-09-26

13:30 - 14:00 : c17-How to induce neuroplastic alterations non-invasively

00:34:15.03

2012-09-26

14:00 - 14:30 : c18-Brain Computer Interfaces (BCI) in paralysis and psychologica...

00:25:48.02

2012-09-26

14:50 - 15:10 : c20-Pain relief with transcranial magnetic stimulation: what are ...

00:23:39.04

2012-09-26

15:10 - 15:25 : c21-Brain plasticity sustained by environmental enrichment: hopes...

00:04:40.03

2012-09-26

15:25 - 15:30 : Clôture

Contact Webcast

La cellule webcast du CCIN2P3 vous propose de diffuser en direct et/ou en différé sur internet vos manifestations, colloques, conférences. Attention, ce service est réservé au domaine public dans le domaine de la Recherche Scientifique.


Cellule Webcast
Centre de Calcul IN2P3/CNRS
21 Avenue Pierre de Coubertin
CS70202
69627 VILLEURBANNE Cedex

Tél. :
+33(0) 4.78.93.08.80

Fax. :
+33(0) 4.72.69.41.70



Email :

Voir les mentions légales du site