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Journées Inaugurales du Centre de Recherche en Neurosciences de Lyon (CRNL)
c4-VEGF in neuronal development and synaptic plasticity (3904) - Mardi 25 septembre 2012 15:20 - 15:40

c4-VEGF in neuronal development and synaptic plasticity

VEGF, for vascular endothelial growth factor, is a prototypic angiogenic factor that was originally known for its critical role in blood vessel formation. Emerging evidence however has revealed that VEGF also regulates a wide range of developmental and adult neurobiological processes, including neurogenesis, neuroprotection and axon guidance. This lecture highlights recent advances in understanding how VEGF directly affects neuronal guidance, referring to studies that employed various mouse models to demonstrate the requirement for VEGF / VEGF receptor signaling. Novel findings uncovered the underlying molecular mechanism involving a cross-talk between VEGF, its receptor VEGFR and the glutamate receptor NMDAR, that is able to modulate non-synaptic NMDAR function. The implication of such a cross-talk between an angiogenic factor and a classic receptor of a neurotransmitter will be discussed in the context of the regulation of hippocampal synaptic transmission.

Claire MEISSIREL, CRNL/Oncoflam

Sciences du Vivant Communication

Toutes les vidéos de l'évenement Journées Inaugurales du Centre de Recherche en Neurosciences de Lyon (CRNL) (20 videos)

00:28:00.03

2012-09-25

10:45 - 11:45 : Ouverture du colloque

00:27:55.04

2012-09-25

11:45 - 12:15 : Brain against brain: presentation of a new brain computer interfa...

00:35:06.02

2012-09-25

14:30 - 15:00 : C2-Multiple level interactions between neurodegeneration and neur...

00:19:24.03

2012-09-25

15:00 - 15:20 : C3-Serotonin receptors and neurodegenerative processes. A Focus o...

00:18:55.03

2012-09-25

15:20 - 15:40 : c4-VEGF in neuronal development and synaptic plasticity

00:19:42.03

2012-09-25

15:40 - 16:00 : C5-Mutations in U4atac small nuclear RNA: from splicing to brain ...

00:36:52.02

2012-09-25

16:30 - 17:00 : c6-Homeostatic regulation of neural activity across the sleep- wa...

00:30:35.02

2012-09-25

17:00 - 17:30 : c7-The neural correlates of conscious awareness revealed by the s...

00:20:25.03

2012-09-25

17:30 - 17:50 : c8-Cognition markers in altered states of consciousness

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2012-09-25

17:50 - 18:10 : C9-The multiple faces of wakefulness, histaminergic and orexinerg...

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2012-09-25

18:10 - 18:30 : c10-Mechanisms responsible for Paradoxical (REM) sleep genesis: w...

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2012-09-26

09:30 - 10:00 : c12-How temporal expectations change perception

00:24:37.04

2012-09-26

10:20 - 10:40 : c14-High-frequency neural activity and human cognition: insights ...

00:20:35.04

2012-09-26

10:40 - 11:00 : c15-Neuroimagery of olfactory perception and memory in humans

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2012-09-26

11:00 - 11:20 : c16-Language, music, complex sounds: What to expect?-And when

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2012-09-26

13:30 - 14:00 : c17-How to induce neuroplastic alterations non-invasively

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2012-09-26

14:00 - 14:30 : c18-Brain Computer Interfaces (BCI) in paralysis and psychologica...

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2012-09-26

14:50 - 15:10 : c20-Pain relief with transcranial magnetic stimulation: what are ...

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2012-09-26

15:10 - 15:25 : c21-Brain plasticity sustained by environmental enrichment: hopes...

00:04:40.03

2012-09-26

15:25 - 15:30 : Clôture

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