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Journées Inaugurales du Centre de Recherche en Neurosciences de Lyon (CRNL)
c10-Mechanisms responsible for Paradoxical (REM) sleep genesis: where are we 50 years after its discovery by Michel Jouvet? (3910) - Mardi 25 septembre 2012 18:10 - 18:30

c10-Mechanisms responsible for Paradoxical (REM) sleep genesis: where are we 50 years after its discovery by Michel Jouvet?

Paradoxical or REM sleep characterized by cortical activation combined with muscle atonia and rapid eye movements has been discovered at the end of the fifties by Michel Jouvet and William C. Dement. The studies of the next twenty years suggested that the onset and maintenance of paradoxical sleep is due to a reciprocal inhibitory interaction between brainstem monoaminergic neurons inhibiting PS (PS-off neurons) and cholinergic neurons generating PS (PS-on neurons) localized in a small nucleus of the pontine reticular formation named sublaterodorsal tegmental nucleus. In my talk, I will review our most recent studies indicating that the key PS-off and PS-on neurons are in fact GABAergic and glutamatergic. Further, I will show that two populations of brainstem PS-on GABAergic neurons and a population of hypothalamic PS-on neurons co-expressing GABA and a peptide, melanin concentrating hormone play crucial roles in PS control. These new results might open new avenues for treatments of pathologies such as narcolepsy, REM sleep behaviour disorder and sleep apnea.

Pierre-Herve? LUPPI, CRNL/Sleep

Sciences du Vivant Communication

Toutes les vidéos de l'évenement Journées Inaugurales du Centre de Recherche en Neurosciences de Lyon (CRNL) (20 videos)

00:28:00.03

2012-09-25

10:45 - 11:45 : Ouverture du colloque

00:27:55.04

2012-09-25

11:45 - 12:15 : Brain against brain: presentation of a new brain computer interfa...

00:35:06.02

2012-09-25

14:30 - 15:00 : C2-Multiple level interactions between neurodegeneration and neur...

00:19:24.03

2012-09-25

15:00 - 15:20 : C3-Serotonin receptors and neurodegenerative processes. A Focus o...

00:18:55.03

2012-09-25

15:20 - 15:40 : c4-VEGF in neuronal development and synaptic plasticity

00:19:42.03

2012-09-25

15:40 - 16:00 : C5-Mutations in U4atac small nuclear RNA: from splicing to brain ...

00:36:52.02

2012-09-25

16:30 - 17:00 : c6-Homeostatic regulation of neural activity across the sleep- wa...

00:30:35.02

2012-09-25

17:00 - 17:30 : c7-The neural correlates of conscious awareness revealed by the s...

00:20:25.03

2012-09-25

17:30 - 17:50 : c8-Cognition markers in altered states of consciousness

00:26:26.03

2012-09-25

17:50 - 18:10 : C9-The multiple faces of wakefulness, histaminergic and orexinerg...

00:19:02.02

2012-09-25

18:10 - 18:30 : c10-Mechanisms responsible for Paradoxical (REM) sleep genesis: w...

00:38:35.02

2012-09-26

09:30 - 10:00 : c12-How temporal expectations change perception

00:24:37.04

2012-09-26

10:20 - 10:40 : c14-High-frequency neural activity and human cognition: insights ...

00:20:35.04

2012-09-26

10:40 - 11:00 : c15-Neuroimagery of olfactory perception and memory in humans

00:20:49.02

2012-09-26

11:00 - 11:20 : c16-Language, music, complex sounds: What to expect?-And when

00:32:32.04

2012-09-26

13:30 - 14:00 : c17-How to induce neuroplastic alterations non-invasively

00:34:15.03

2012-09-26

14:00 - 14:30 : c18-Brain Computer Interfaces (BCI) in paralysis and psychologica...

00:25:48.02

2012-09-26

14:50 - 15:10 : c20-Pain relief with transcranial magnetic stimulation: what are ...

00:23:39.04

2012-09-26

15:10 - 15:25 : c21-Brain plasticity sustained by environmental enrichment: hopes...

00:04:40.03

2012-09-26

15:25 - 15:30 : Clôture

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